1. Chronic Pain Management
The use of cannabis/marijuana to treat chronic pain has had a long history, with written references of its use dating back to around 2700 B.C.E. The first records in the nineteenth century were recorded by the Irish doctor William B. O’Shaughnessy, who described the use of cannabis in the treatment of cholera, rabies, tetanus, menstrual cramps and delirium tremens. In modern times, significant research has been done around cannabis therapy in the treatment of chronic pain with very promising results.
In recent years, scientists have become increasingly aware of the endocannabinoid system’s role in regulating sleep. In addition to maintaining a regular sleep pattern, the system, which is responsible for the effects of marijuana, has been identified as a potential target for the treatment of insomnia. Studies show that endocannabinoids increase sleepiness and that insomnia may even be caused by a dysfunctional endocannabinoid system.
3. Anxiety Control
Cannabis’ ingredients have been proven to act on nerve cells to dampen anxiety and provide relief to sufferers. Anxiety, however, can also be an unwanted side effect of using cannabis with too much of pot’s main active ingredient, THC, so anxiety sufferers should stay away from high-THC strains unless they have built up a tolerance. However, certain other molecules in cannabis like CBD and THC-V have shown effectiveness in decreasing anxiety.
4. Marijuana can be used to treat Glaucoma.
Marijuana use can be used to treat and prevent the eye disease glaucoma, which increases pressure in the eyeball, damaging the optic nerve and causing loss of vision. Marijuana decreases the pressure inside the eye, according to the National Eye Institute: “Studies in the early 1970s showed that marijuana, when smoked, lowered intraocular pressure (IOP) in people with normal pressure and those with glaucoma.” These effects of the drug may slow the progression of the disease, preventing blindness.
5. Marijuana reduces some of the awful pain and nausea from chemo, and stimulates appetite.
There is strong evidence that the cannabinoids naturally produced in the body play a role in suppressing nausea in normal circumstances, and intake of cannabinoids from medical marijuana during episodes of nausea can also effectively relieve symptoms. The body absorbs medical marijuana quickly because it is similar to the cannabinoids the body naturally produces. More cannabinoids are absorbed in inhaled form than in ingested form, since the body attempts to metabolize any ingested medication before absorption. This action also reduces the effectiveness of standard therapies, including synthetic cannabis.
One of the most well-known medical uses of marijuana is for people going through chemotherapy. Cancer patients being treated with chemo suffer from painful nausea, vomiting, and loss of appetite. This can cause additional health complications. Marijuana can help reduce these side effects, alleviating pain, decreasing nausea, and stimulating the appetite.
6. Marijuana can help control epileptic seizures.
Marijuana use can prevent epileptic seizures in rats, a 2003 study showed. Robert J. DeLorenzo, of Virginia Commonwealth University, gave marijuana extract and synthetic marijuana to epileptic rats. The drugs rid the rats of the seizures for about 10 hours. Cannabinoids like the active ingredients in marijuana,tetrahydrocannabinol (also known as THC), control seizures by binding to the brain cells responsible for controlling excitability and regulating relaxation. The findings were published in the Journal of Pharmacology and Experimental Therapeutics.
7. Marijuana also decreases the symptoms of a severe seizure disorder known as Dravet’s Syndrome.
During the research for his documentary “Weed,” Sanjay Gupta interviewed the Figi family, who treats their 5-year-old daughter using a medical marijuana strain high in cannabidiol and low in THC.
There are at least two major active chemicals in marijuana that researchers think have medicinal applications (there are up to 79 known active compounds). Those two are cannabidiol (CBD) — which seems to impact the brain mostly without a high— and tetrahydrocannabinol (THC) — which has pain relieving (and other) properties.
The Figi family’s daughter, Charlotte, has Dravet Syndrome, which causes seizures and severe developmental delays.
According to the film, the drug has decreased her seizures from 300 a week to just one every seven days. Forty other children in the state are using the same strain of marijuana (which is high in CBD and low in THC) to treat their seizures — and it seems to be working.
The doctors who recommended this treatment say that the cannabidiol in the plant interacts with the brain cells to quiet the excessive activity in the brain that causes these seizures.
As Gutpa notes, a Florida hospital that specializes in the disorder, the American Academy of Pediatrics, and the Drug Enforcement agency don’t endorse marijuana as a treatment for Dravet or other seizure disorders.
8. A chemical found in marijuana stops cancer cells from spreading in the lab.
CBD may also help prevent cancer from spreading, researchers at California Pacific Medical Center in San Francisco reported in 2007.
Cannabidiol stops cancer by turning off a gene called Id-1, the study, published in the journal Molecular Cancer Therapeutics, found. Cancer cells make more copies of this gene than non-cancerous cells, and it helps them spread through the body.
The researchers studied breast cancer cells in the lab that had high expression levels of Id-1 and treated them with cannabidiol. After treatment the cells had decreased Id-1 expression and were less aggressive spreaders. But beware: these are studies on cancer cells in the lab, not on cancer patients.
Other very preliminary studies on aggressive brain tumors in mice or cell cultures have shown that THC and CBD can slow or shrink tumors at the right dose, which is a great reason to do more research into figuring out that dose.
One 2014 study found that marijuana can significantly slow the growth of the type of brain tumor associated with 80% of malignant brain cancer in people.
In “WEED,” Gupta also mentioned a few studies in the U.S., Spain, and Israel that suggest the compounds in cannabis could even kill cancer cells.
9. THC may slow the progression of Alzheimer’s disease.
Marijuana may be able to slow the progression of Alzheimer’s disease, a study led by Kim Janda of the Scripps Research Institute suggests. The 2006 study, published in the journal Molecular Pharmaceutics, found that THC, the active chemical in marijuana, slows the formation of amyloid plaques by blocking the enzyme in the brain that makes them. These plaques seem to be what kill brain cells and potentially cause Alzheimer’s. A synthetic mixture of CBD and THC seem to preserve memory in a mouse model of Alzheimer’s disease. Another study suggested that in population-based studies, a THC-based prescription drug called dronabinol was able to reduce behavioral disturbances in dementia patients.
10. Marijuana may eases the pain of multiple sclerosis.
Marijuana may ease painful symptoms of multiple sclerosis, a study published in the Canadian Medical Association Journal in May suggests. Jody Corey-Bloom studied 30 multiple sclerosis patients with painful contractions in their muscles. These patients didn’t respond to other treatments, but after smoking marijuana for a few days they reported that they were in less pain. The THC in the pot binds to receptors in the nerves and muscles to relieve pain. Other studies suggest that the chemical also helps control the muscle spasms.
11. Marijuana lessens side effects from treating hepatitis C and increases treatment effectiveness.
Treatment for hepatitis C infection is harsh — negative side effects include fatigue, nausea, muscle aches, loss of appetite, and depression — and lasts for months. Many people aren’t able to finish their treatment course because of the side effects. But, pot to the rescue: A 2006 study in the European Journal of Gastroenterology and Hepatology found that 86% of patients using marijuana successfully completed their Hep C therapy, while only 29% of non-smokers completed their treatment, possibly because the marijuana helps lessens the treatments side effects. Marijuana also seems to improve the treatment’s effectiveness: 54% of hep C patients smoking marijuana got their viral levels low and kept them low, in comparison to only 8% of nonsmokers.
12. Marijuana treats inflammatory bowel diseases, including Crohn’s disease.
Patients with inflammatory bowel diseases like Crohn’s disease and ulcerative colitis could benefit from marijuana use, studies suggest. University of Nottingham researchers found in 2010 that chemicals in marijuana, including THC and cannabidiol, interact with cells in the body that play an important role in gut function and immune responses. The study was published in the Journal of Pharmacology and Experimental Therapeutics. THC-like compounds made by the body increase the permeability of the intestines, allowing bacteria in. The plant-derived cannabinoids in marijuana block these body-cannabinoids, preventing this permeability and making the intestinal cells bond together tighter. One study in Israel showed that smoking a joint significantly reduced Crohn’s disease symptoms in 10 out of 11 patients compared to a placebo and without side effects. That’s a small study, but other research has shown similar effects. Even more research finds that people with Crohn’s and other inflammatory bowel disorders use cannabis to help deal with their symptoms, even if there are questions about how much marijuana can or can’t help.
13. Marijuana relieves arthritis discomfort.
Marijuana alleviates pain, reduces inflammation, and promotes sleep, which may help relieve pain and discomfort for people with rheumatoid arthritis, researchers announced in 2011.
Medical marijuana is also being used to treat the autoimmune disease Systemic Lupus Ertyhematosus, which is when the body starts attacking itself for some unknown reason. Both THC and CBD have anti-inflammatory properties, which may be how cannabis helps deal with symptoms of Lupus and arthritis. The rest of the positive impact of the marijuana is probably from the effects on pain and nausea. Researchers from rheumatology units at several hospitals gave their patients Sativex, a cannabinoid-based pain-relieving medicine. After a two-week period, people on Sativex had a significant reduction in pain and improved sleep quality compared to placebo users. A note of caution, though, a recent study in Arthritis Care & Research suggests there isn’t enough evidence to back up the use of marijuana for these kinds of diseases, mostly because there aren’t comprehensive studies on the side effects and little regulation of dosage and consistency in the chemical make up of medical marijuana.
14. While not really a health benefit, marijuana spurs creativity in the brain.
Contrary to stoner stereotypes, marijuana usage has actually been shown to have some positive mental effects, particularly in terms of increasing creativity. Even though people’s short-term memories tend to function worse when high, people get better at tests requiring them to come up with new ideas. One study tested participants on their ability to come up with different words related to a concept, and found that using cannabis allowed people to come up with a greater range of related concepts, seeming “to make the brain better at detecting those remote associations that lead to radically new ideas,” according to Wired. Other researchers have found that some participants improve their “verbal fluency,” their ability to come up with different words, while using marijuana. Part of this increased creative ability may come from the release of dopamine in the brain, lessening inhibitions and allowing people to feel more relaxed, giving the brain the ability to perceive things differently.
15. Marijuana soothes tremors for people with Parkinson’s disease.
16. Marijuana helps veterans suffering from PTSD.
The Colorado Department of Public Health recently awarded $2 million to the Multidisciplinary Association for Psychedelic Studies (MAPS is one of the biggest proponents of marijuana research) to study marijuana’s potential as part of treatment for people with post-traumatic stress disorder. Marijuana is approved to treat PTSD in some states already — in New Mexico, PTSD is the number one reason for people to get a license for medical marijuana. Naturally occurring cannabinoids, similar to THC, help regulate the system that causes fear and anxiety in the body and brain. But there are still questions about the safety of using marijuana while suffering from PTSD, which this study will hopefully help answer.
17. Marijuana may help protect the brain after a stroke or concussion.
Research from the University of Nottingham shows that marijuana may help protect the brain from damage caused by stroke, by reducing the size of the area affected by the stroke — at least in rats, mice, and monkeys. This isn’t the only research that has shown neuroprotective effects from cannabis. Some research shows that the plant may help protect the brain after other traumatic events, like concussions.
There is some evidence that marijuana can help heal the brain after a concussion or other traumatic injury. A recent study in the journal Cerebral Cortex showed that in mice, marijuana lessened the bruising of the brain and helped with healing mechanisms after a traumatic injury. Harvard professor emeritus of psychiatry and marijuana advocate Lester Grinspoon recently wrote an open letter to NFL Commissioner Roger Goodell, saying the NFL should stop testing players for marijuana, and that the league should start funding research into the plant’s ability to protect the brain.
“Already, many doctors and researchers believe that marijuana has incredibly powerful neuroprotective properties, an understanding based on both laboratory and clinical data,” he writes. Goodell recently said that he’d consider permitting athletes to use marijuana if medical research shows that it’s an effective neuroprotective agent.
18. Marijuana can help eliminate nightmares.
This is a complicated one, because it involves effects that can be both positive and negative. Marijuana disturbs sleep cycles by interrupting the later stages of REM sleep. In the long run, this could be a problem for frequent users. However, for people suffering from serious nightmares, especially those associated with PTSD, this can be helpful. Nightmares and other dreams occur during those same stages of sleep. By interrupting REM sleep, many of those dreams may not occur. Research into using a synthetic cannabinoid, like THC, but not the same, showed a significant decrease in the number of nightmares in patients with PTSD. Additionally, even if frequent use can be bad for sleep, marijuana may be a better sleep aid than some other substances that people use. Some of those, including medication and alcohol, may potentially have even worse effects on sleep, though more research is needed on the topic.